酶响应型可裂解连接子
该类化合物属于抗体偶联药物（ADC）开发中的关键中间体，其设计融合了靶向连接、可裂解释放及高效细胞毒素模块，是当前ADC技术中“连接子-毒素”（linker-payload）的典型代表。
其中PEG链提供亲水性和空间位阻，Glucuronide(葡萄糖醛酸)作为可裂解连接子，MABC作为自毁连接子(对氨基苯甲酸甲酯)，Exatecan则是拓扑异构酶I抑制剂类毒素。
其中PEG链提供亲水性和空间位阻，Glucuronide(葡萄糖醛酸)作为可裂解连接子，MABC作为自毁连接子(对氨基苯甲酸甲酯)，Exatecan则是拓扑异构酶I抑制剂类毒素。
客户近期使用本公司产品发表的高影响因子论文（IF>10）
- Intelligent Nano-Cage for Precision Delivery of CRISPR-Cas9 and ACC Inhibitors to Enhance Antitumor Cascade Therapy Through Lipid Metabolism Disruption
- Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment
- A Versatile One-Step Enzymatic Strategy for Efficient Imaging and Mapping of Tumor-Associated Tn Antigen
- Surface-anchored tumor microenvironment-responsive protein nanogel-platelet system for cytosolic delivery of therapeutic protein in the post-surgical cancer treatment
- Genetically Incorporated Non-Canonical Amino Acids
- Boosting Dye-Sensitized Luminescence by Enhanced Short-Range Triplet Energy Transfer
- Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling
- Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling
- A proof-of-concept study on bioorthogonal-based pretargeting and signal amplify radiotheranostic strategy
- Bioengineered Platelets Combining Chemotherapy and Immunotherapy for Postsurgical Melanoma Treatment: Internal Core-Loaded Doxorubicin and External Surface-Anchored Anti-PDL1 Antibody Backpacks
- Scalable Synthesis of Highly Stable Cyclopropene Building Blocks: Application for Bioorthogonal Ligation with Tetrazines
- Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates
- Reversible control of tetrazine bioorthogonal reactivity by naphthotube-mediated host-guest recognition
- An Optimized Isotopic Photocleavable Tagging Strategy for SiteSpecific and Quantitative Profiling of Protein O‑GlcNAcylation in Colorectal Cancer Metastasis
西安点化生物科技有限公司独家代理本公司产品,已入驻以下试剂采购平台
可直接点击对应链接跳转下单
