小分子偶联药物(SMDC)
生物素修饰的阿霉素由小分子靶向配体(生物素)+连接臂 + 细胞毒药物(阿霉素)构成 ,本质上构建了一个"靶向递送+治疗监控"的双功能系统。主要用于细胞成像与追踪、药物递送与释放、免疫分析与检测等科研领域。
客户近期使用本公司产品发表的高影响因子论文(IF>10)
- Intelligent Nano-Cage for Precision Delivery of CRISPR-Cas9 and ACC Inhibitors to Enhance Antitumor Cascade Therapy Through Lipid Metabolism Disruption
- Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment
- A Versatile One-Step Enzymatic Strategy for Efficient Imaging and Mapping of Tumor-Associated Tn Antigen
- Surface-anchored tumor microenvironment-responsive protein nanogel-platelet system for cytosolic delivery of therapeutic protein in the post-surgical cancer treatment
- Genetically Incorporated Non-Canonical Amino Acids
- Boosting Dye-Sensitized Luminescence by Enhanced Short-Range Triplet Energy Transfer
- Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling
- Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling
- A proof-of-concept study on bioorthogonal-based pretargeting and signal amplify radiotheranostic strategy
- Bioengineered Platelets Combining Chemotherapy and Immunotherapy for Postsurgical Melanoma Treatment: Internal Core-Loaded Doxorubicin and External Surface-Anchored Anti-PDL1 Antibody Backpacks
- Scalable Synthesis of Highly Stable Cyclopropene Building Blocks: Application for Bioorthogonal Ligation with Tetrazines
- Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates
- Reversible control of tetrazine bioorthogonal reactivity by naphthotube-mediated host-guest recognition
- An Optimized Isotopic Photocleavable Tagging Strategy for SiteSpecific and Quantitative Profiling of Protein O‑GlcNAcylation in Colorectal Cancer Metastasis